Thin layer coulometry of nitrite with ion-selective membranes

M Afshar; G A Crespo; D Dorokhin; B Neel; Eric Bakker

doi:10.1002/elan.201400522

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Thin layer coulometry of nitrite with ion-selective membranes

Journal article

Peer reviewed

Thin layer coulometry of nitrite with ion-selective membranes

M Afshar, G A Crespo, D Dorokhin, B Neel and Eric Bakker

Electroanalysis, Vol.27(3), pp.609-615

2015

DOI: https://doi.org/10.1002/elan.201400522

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Abstract

Analytical Chemistry

Physical Chemistry (incl. Structural)

Other Chemical Sciences

thin layer coulometry

ion-selective membranes

nitrite detection

universal detection systems

urine analysis

salophen

We report on a thin layer coulometric detection method based on an ion-selective membrane in view of a quantitative determination of nitrite in undiluted human urine and tap water. A cobalt(II) tert-butyl salophen compound, previously characterized by our group in ion-selective membrane electrodes, is used here as ionophore. The four orders of magnitude discrimination of chloride permits the detection of nitrite in samples that contain a large excess of chloride. The approach developed here allows one to determine nitrite within a concentration range of 20-100μM for a 120s current integration time. A modification of the reported electrochemical protocol to reduce the capacitive contribution diminishes the intercept of the calibration to -8.6μC. This is especially important in view of reaching calibration free systems. Initial in-house validation exhibits a limit of detection of 10μM in undiluted urine and in tap water. These values correspond to the regulation limits established in European Union and are adequate for the determination of nitrite for medical applications.

Details

Title: Thin layer coulometry of nitrite with ion-selective membranes
Authors: M Afshar (Author) - University of Geneva, Switzerland
G A Crespo (Author) - University of Geneva, Switzerland
D Dorokhin (Author) - University of Geneva, Switzerland
B Neel (Author) - University of Geneva, Switzerland
Eric Bakker (Author) - University of Geneva, Switzerland
Publication details: Electroanalysis, Vol.27(3), pp.609-615
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Date published: 2015
DOI: 10.1002/elan.201400522
ISSN: 1040-0397; 1040-0397
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449288602621
Output Type: Journal article

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Web Of Science research areas: Chemistry, Analytical; Electrochemistry