IQdb: An intelligence quotient score-associated gene resource for human intelligence

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IQdb: An intelligence quotient score-associated gene resource for human intelligence

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Title: IQdb: An intelligence quotient score-associated gene resource for human intelligence
Author/Creator: Kong, L | Cheng, L | Fan, L Y | Zhao, Min | Qu, H
Description: Intelligence quotient (IQ) is the most widely used phenotype to characterize human cognitive abilities. Recent advances in studies on human intelligence have identified many new susceptibility genes. However, the genetic mechanisms involved in IQ score and the relationship between IQ score and the risk of mental disorders have won little attention. To address the genetic complexity of IQ score, we have developed IQdb (http://IQdb.cbi.pku.edu.cn), a publicly available database for exploring IQ-associated human genes. In total, we collected 158 experimental verified genes from literature as a core dataset in IQdb. In addition, 46 genomic regions related to IQ score have been curated from literature. Based on the core dataset and 46 confirmed linked genomic regions, more than 6932 potential IQ-related genes are expanded using data of protein-protein interactions. A systematic gene ranking approach was applied to all the collected and expanded genes to represent the relative importance of all the 7090 genes in IQdb. Our further systematic pathway analysis reveals that IQ-associated genes are significantly enriched in multiple signal events, especially related to cognitive systems. Of the 158 genes in the core dataset, 81 are involved in various psychotic and mental disorders. This comprehensive gene resource illustrates the importance of IQdb to our understanding on human intelligence, and highlights the utility of IQdb for elucidating the functions of IQ-associated genes and the cross-talk mechanisms among cognition-related pathways in some mental disorders for community. © The Author(s) 2013. Published by Oxford University Press.
Relation: Database / Vol. 2013
Relation: http://dx.doi.org/10.1093/database/bat063
Year: 2013
Publisher: Oxford University Press
Subject: FoR 0804 (Data Format) | FoR 0807 (Library and Information Studies) | computer interface | genetic association | genetic database | genetics | human | human genome | intelligence | intelligence test | Internet | molecular genetics | protein protein interaction | databases | genetic | genetic association studies | genome | human

Collection(s): Research Publications
Resource Type: Journal Article
Identifier: ISSN: 1758-0463
Rights: Copyright © The Author(s) 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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