Chlamydia pneumoniae: Modern insights into an ancient pathogen

E Roulis; Adam Polkinghorne; Peter Timms

doi:10.1016/j.tim.2012.10.009

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Chlamydia pneumoniae: Modern insights into an ancient pathogen

Journal article

Open access

Peer reviewed

Chlamydia pneumoniae: Modern insights into an ancient pathogen

E Roulis, Adam Polkinghorne and Peter Timms

Trends in Microbiology, Vol.21(3), pp.120-128

2013

DOI: https://doi.org/10.1016/j.tim.2012.10.009

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Abstract

Chlamydia pneumoniae

infection

genomics

cell biology

human

zoonosis

Chlamydia pneumoniae is an enigmatic human and animal pathogen. Originally discovered in association with acute human respiratory disease, it is now associated with a remarkably wide range of chronic diseases as well as having a cosmopolitan distribution within the animal kingdom. Molecular typing studies suggest that animal strains are ancestral to human strains and that C. pneumoniae crossed from animals to humans as the result of at least one relatively recent zoonotic event. Whole genome analyses appear to support this concept - the human strains are highly conserved whereas the single animal strain that has been fully sequenced has a larger genome with several notable differences. When compared to the other, better known chlamydial species that is implicated in human infection, Chlamydia trachomatis, C. pneumoniae demonstrates pertinent differences in its cell biology, development, and genome structure. Here, we examine the characteristic facets of C. pneumoniae biology, offering insights into the diversity and evolution of this silent and ancient pathogen. © 2012.

Details

Title: Chlamydia pneumoniae: Modern insights into an ancient pathogen
Authors: E Roulis (Author) - Queensland University of Technology
Adam Polkinghorne (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
Publication details: Trends in Microbiology, Vol.21(3), pp.120-128
Publisher: Elsevier Ltd.
Date published: 2013
DOI: 10.1016/j.tim.2012.10.009
ISSN: 0966-842X
Grants: Specificity of Chlamydia pneumoniae for humans: analysis of previous cross-host transmission events and the role of tryptophan availability in host specificity, 1004666, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Organisation Unit: Centre for Bioinnovation
Language: English
Record Identifier: 99449039702621
Output Type: Journal article

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