Poly-Immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection

K A Cunningham; A J Carey; J M Finnie; S Bao; C Coon; R Jones; O Wijburg; R A Strugnell; Peter Timms; K W Beagley

doi:10.1111/j.1600-0897.2008.00637.x

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Poly-Immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection

Journal article

Peer reviewed

Poly-Immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection

K A Cunningham, A J Carey, J M Finnie, S Bao, C Coon, R Jones, O Wijburg, R A Strugnell, Peter Timms and K W Beagley

American Journal of Reproductive Immunology, Vol.60(5), pp.405-414

2008

DOI: https://doi.org/10.1111/j.1600-0897.2008.00637.x

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Abstract

Chlamydia

IgA

poly-immunoglobulin receptor

Problem: Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility. Method of study: We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL/6 and pIgR-/- mice. Results: Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo. Conclusion: These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.

Details

Title: Poly-Immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection
Authors: K A Cunningham (Author) - Queensland University of Technology
A J Carey (Author) - Queensland University of Technology
J M Finnie (Author) - University of Newcastle
S Bao (Author) - University of Sydney
C Coon (Author) - University of Sydney
R Jones (Author) - University of Newcastle
O Wijburg (Author) - University of Melbourne
R A Strugnell (Author) - University of Melbourne
Peter Timms (Author) - Queensland University of Technology
K W Beagley (Author) - Queensland University of Technology
Publication details: American Journal of Reproductive Immunology, Vol.60(5), pp.405-414
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2008
DOI: 10.1111/j.1600-0897.2008.00637.x
ISSN: 1046-7408; 1046-7408
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448879902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Reproductive Biology

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